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Mammalian Cell Membrane Hybrid Polymersomes for mRNA Delivery
Cell membranes fused with synthetic nanoparticles create hybrid polymersomes (HyPSomes) for improved vaccine delivery. These HyPSomes mimic cell antigenic properties, enhance mRNA delivery, ensure stability, and facilitate endosome escape, with potential applications in vaccines, diagnostics, and drug delivery.
Dual-targeted nano-encapsulation of neonatal porcine islet-like cell clusters with triiodothyronine-loaded bifunctional polymersomes
Polymersomes (PSomes) with NHS and Mal groups enable dual targeting, effectively protecting NPCCs from xenoantigens. Encapsulation of T3 enhances NPCC maturation, glucose sensitivity, and insulin secretion. This nano-encapsulation method addresses graft rejection and NPCC immaturity, advancing islet cell therapy for type 1 diabetes.
Charge-Complementary Polymersomes for Enhanced mRNA Delivery
ChargeSome nanoparticles are pH-responsive nanocarriers engineered to disassemble under acidic conditions (pH ≤ 5.5), enabling the release of encapsulated genetic material. Upon endocytosis, these nanoparticles destabilize the endosomal membrane, promoting endosomal escape and efficient cytoplasmic delivery of therapeutic genes.