Research
ResearchDiagnosis
Diagnosis
Detection of Alzheimer’s Disease Biomarker using Anti-NFL Antibody Conjugated Gold Nanoparticles
Neurofilament light chain (NFL), a biomarker for early-stage Alzheimer’s disease, is detected using antibody-conjugated gold nanoparticles (ACNP) prepared via EDC/NHS-mediated surface modification. The ACNP bind specifically to NFL, enabling detection through absorbance changes without the need for expensive equipment. This cost-effective and selective platform offers a promising method for diagnosing neuronal damage by measuring NFL levels.
Swine Fever (ASFV) Early Detection System using Gold Nanoparticle-DNA Probes
African swine fever virus (ASFV), a highly fatal DNA virus, can be efficiently detected through a gold nanoparticle (GNP)-DNA probe system that leverages colorimetric changes caused by GNP aggregation upon target DNA binding. The system enables rapid, on-site diagnosis without specialized equipment, with complementary DNA sequences inducing visible aggregation, while non-target DNA remains dispersed.